ZRAY Introduces Pharmaceutical Box Erecting and Sealing Equipment (60–80 boxes/min, HEPA H13, GMP) with Zero-Dust Operation | ZRAY
Pharmaceutical cartoning has zero tolerance for loose fibre or paper dust. A single stray particle settling on a blister card or vial label is a batch record deviation, a customer complaint and often a recall. Yet every erector is, by nature, a dust generator: the blank’s cutting edge, magazine friction and the air burst when a carton pops open. ZRAY’s new pharmaceutical box erecting and sealing equipment is engineered around a sealed, negative-pressure forming chamber with HEPA H13 extraction, holding a verified clean state at 60–80 boxes per minute while meeting GMP expectations for contact surfaces and cleanability.
Zero-Dust Engineering Plan
| Dust source | Countermeasure |
|---|---|
| Blank cutting edge | Enclosed trim capture at exit |
| Magazine friction | Low-friction guides, anti-static liners |
| Opening burst | Sealed chamber + negative-pressure extraction |
| Fine fibre | HEPA H13, 0.3 µm at 99.97% |
| Static | Ionised-air bar before forming |
The extraction runs continuously; air is pulled through the H13 filter before any recirculation, so fibre never returns to the carton path.
GMP Compliance Points
Product-contact parts are 304 stainless steel, fully welded with no dead corners, shedding fasteners or open threads in the pharma zone. Every surface suits the plant’s validated cleaning agent and the design supports cleaning validation with documented rinse limits.
Cleanliness and Static Control
| Parameter | Target |
|---|---|
| Surface resistance | < 10⁹ Ω (anti-static) |
| Ioniser air speed | 0.5–1.0 m/s at carton |
| Particle count (≥0.5 µm) | Below ISO 8 at chamber exit |
| Extraction pressure | −20 to −50 Pa negative |
Pharmaceutical Carton Specification
| Parameter | Range |
|---|---|
| Carton length (L) | 60–200 mm |
| Carton width (W) | 40–120 mm |
| Carton height (H) | 20–80 mm |
| Speed | 60–80 boxes/min |
| Coding interface | Emboss / inkjet / serialisation |
| Board | 200–450 g/m², pharma grade |
Flute direction and humidity follow the same industrial rules; off-spec board is rejected at load.
Validation Document Package
Each machine ships with an IQ/OQ/PQ package, material certificates for all 304 contact parts and a surface-roughness report (Ra ≤ 0.8 µm). Optional 21 CFR Part 11 audit-trail logging is available on the HMI.
Error-Proofing and Traceability
A barcode check at the infeed confirms the correct carton before erection; mismatched or damaged blanks are rejected by a pneumatic arm and logged. With the audit-trail option on, every reject, parameter change and operator login is recorded for the batch record.
Preventive Maintenance Schedule
| Interval | Tasks |
|---|---|
| Daily | Clean chamber; check H13 differential pressure; verify ioniser; test reject |
| Weekly | Replace pre-filter if loaded; sanitise 304 surfaces; check seals |
| Monthly | Record filter pressure trend; calibrate coding; review audit log |
| Quarterly | Replace H13 element per differential; verify particle count |
| Annually | Full IQ re-check; re-level; audit 21 CFR Part 11 settings |
Field Alarm Codes
| Code | Description | Field action |
|---|---|---|
| AL-02 | Magazine empty | Reload pharma-grade carton |
| AL-04 | Forming jam | Clear, re-set platen to board + 0.5 mm |
| AL-07 | Safety circuit open | Close guard, reset safety relay |
| AL-09 | Air pressure low | Check FRL, drain moisture |
| AL-10 | Encoder / comm fault | Reseat encoder, re-route cables |
| DUST-01 | Filter differential high | Replace H13 / pre-filter element |
Model Selection and Support
For cartons needing a rigid lid after erecting, pair the line with our Rigid Box Capping Machine. For validation paperwork, spare H13 elements and on-site IQ/OQ support, contact ZRAY Support.
Get a Quotation for Your Packaging Line
Send us your carton size range, board grade and required CPM — our engineers will return a model recommendation, layout drawing and quotation within 24 hours.
Contact ZRAY: [email protected] · WhatsApp +86 13681839278
Want To Know More About Our Upgraded Machines?
Send your carton specifications and output demand, our engineer will provide free technical scheme & quotation
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